This chapter addresses a global issue of education: the teaching of diverse student populations. Global Education Professional Development (GEPD) programs for both pre-service and in-service teachers have become one of the most important teacher training programs to prepare teachers working with English as a Second Language (ESL) learners in global classrooms. The goal of this chapter is to design a GEPD model to help educators, administrators, and policy makers to: 1) comprehend current policies, practices, experiences as well as strategies in global classrooms; 2) understand how instructors can help ESL learners adjust to the U.S. academic language and culture and how this support could affect learners' effectiveness, attitudes and confidence; and 3) acquire the knowledge of how to integrate technology into the curriculum and consider technology as meaningful learning environments that could support not only language but also intercultural and global literacy skills.